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時間:2022-08-15 來源:本站 點擊:258次
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Pig kidney works in human patient in 'potential miracle'******

AFP

In this September 25 image courtesy of NYU Langone Health, the surgical team examines the genetically engineered pig kidney for signs of rejection.

A US medical team has succeeded in temporarily attaching a pig's kidney to a person, a transplant breakthrough hailed as a "potential miracle" by the surgeon who led the procedure.

The surgery, carried out on September 25, involved a genetically modified donor animal and a brain-dead patient on a ventilator whose family had given permission for the two-day experiment, for the sake of advancing science.

"It did what it's supposed to do, which is remove waste and make urine," Robert Montgomery, director of the transplant institute at New York University Langone, told AFP.

Critically, the organ was able to reduce the level of the molecule creatinine, a key indicator of kidney health that was elevated in the patient prior to the transplant.

Montgomery carried out the surgery with several colleagues over the course of around two hours.

They joined the kidney to blood vessels on the top of one of the patient's legs, so that they could observe it and take biopsy samples.

The patient had wanted to be an organ donor and their family was initially disappointed when told their loved one's organs were not suitable, said Montgomery.

But "they felt a sense of relief that this was another opportunity for donation," he said. The patient was taken off the ventilator and passed away following the 54-hour test.

AFP

The genetically engineered pig kidney is prepared to allow for urine production.

'Important intermediate step'

Earlier research has shown that kidneys from pigs are viable in nonhuman primates for up to a year, but this was the first time it had been attempted with a human patient.

The donor pig belonged to a herd that had undergone a genetic editing procedure to knock out a gene that produces a particular sugar, which would otherwise have triggered a strong immune response and led to organ rejection.

The editing was performed by biotech firm Revivicor, a subsidiary of United Therapeutics.

"It is still a question what would happen three weeks from now, three months, three years," said Montgomery.

"The only way we're really going to be able to answer that is to move this into a living human trial. But I think this is a really important intermediate step, which tells us that at least initially, things are probably going to be okay."

He plans to submit the findings to a scientific journal in the next month, and says a clinical trial could take place in around a year or two.

The news was welcomed cautiously by outside experts, who nonetheless said they would like to see the peer-reviewed data before drawing firm conclusions.

"This news is a significant scientific achievement in the xenotransplantation field," Hynek Mergental, a surgeon at the University of Birmingham in Britain, said in a statement.

If confirmed, "it would be a major step forward in the organ transplant field that might solve the critical shortage of donor organs," he added.

AFP

A genetically engineered pig kidney is cleaned and prepared for transplant into a person.

Organ shortage

The news comes amid a dire shortage of transplant organs.

According to official US data, there are nearly 107,000 Americans awaiting an organ – 90,000 of whom need a kidney. Seventeen Americans die each day while waiting for an organ.

To meet demand, doctors have long been interested in so-called xenotransplantation, or cross-species organ donation, with experiments tracing back to the 17th century.

Early research focused on harvesting organs from primates – for example, a baboon heart was transplanted into a newborn known as "Baby Fae" in 1984, but she survived only 20 days.

Today, pig heart valves are widely used in humans, and pig skin is grafted on human burn victims.

Pigs make the ideal donors because of their size, their rapid growth and large litters, and the fact they are already raised as a food source, said Montgomery.

张扣扣案二审维持死刑 10个小时庭审都发生了什么******

(原标题:张扣扣被维持死刑判决,10个小时庭审都发生了什么?)

张美玲本文来源:东方网 责任编辑:杨艺_NBJ10647

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甘肃两姐妹被洪水卷走失踪 当地警方不予立案******

(原标题:当地警方不予立案 称家长应负主要责任)

(中国青年报·中青在线记者 章正)甘肃省兰州市红古区委宣传部今天给中国青年报·中青在线记者发来的一份情况说明显示,对于两姐妹被洪水卷走一事(具体见中国青年报·中青在线7月19日报道《甘肃一水电站泄洪 两名女孩被卷走》),兰州市红古区警方认为,这是一起落水儿童失踪的意外事件,不予立案,家长应该负主要责任。

说明称,7月12日15时左右,红古区平安镇夹滩村湟水河道玩耍的两名女童不幸落水失踪。据了解,落水失踪的两名女童年龄分别为8岁和10岁,就读于西固区一小学。事件发生后,红古区平安镇党委、镇政府高度重视,立即将相关情况及时上报红古区委、区政府,动员镇机关干部及夹滩村村民搜救两名落水儿童,同时请求公安、消防部门出动人员赶赴现场全力搜救,镇党委、镇政府对家属进行了安抚慰问,并积极与西固区教育部门联系,通报了情况。

7月13日清晨,平安镇机关干部和夹滩村村民与西固区教育部门相关人员继续开展了搜救工作。搜救中当地政府还动用了无人机。为进一步做好搜救和安抚工作,平安镇成立了以镇党委书记为组长的应急搜救领导小组,并设立了搜救、安抚、舆情等工作组。连日来,各工作小组围绕各自工作职责,发动镇上干部及夹滩村村民沿河道一直进行搜寻。

在情况说明中,红古警方介绍:7月12日15时47分,红古公安分局110指挥中心接到求助电话,报警人称她的两个女孩,一个10岁,一个8岁,在河边玩耍时被水冲走了。接到报警后,指挥中心立即指示平安镇派出所协助搜救。红古警方认为,这是一起落水儿童失踪意外事件,不予立案。对这起意外事件,家长应该负主要责任,家长对孩子监管责任不到位是主要原因。

针对家属反映河道没有设置明显标志一事,红古区水务局有关人员表示:他们查阅了相关资料,也咨询了上级部门专家咨询,法律并无明文规定河道管理人员设置警示标志和保证进入河道人员安全的义务。而且落水失踪地点上游为永靖福川水电站,该水电站属于永靖县审批监管,距离落水失踪地点不到3公里。

平安镇负责人介绍,事件发生后,镇上从人文关怀的角度出发,积极组织人员搜救,并对家属进行安抚慰问,“镇上做了许多工作”。

红古区信访部门表示,其对家属上访反映的诉求做了耐心细致的接待和答复,对家属提出的水电站泄洪造成孩子失踪等问题,区相关部门都作了解释和说明,对其他责任追究的诉求已建议家属通过司法渠道维护权益。

孩子的父亲并不认可警方的说法,他对记者表示:“两个娃娃是在裸露的河边玩,并没有下水,被水电站泄洪两米多高的浪卷走,这是人为原因造成的悲剧。”

他坚称,尽管水电站在临夏永靖县境内,但是孩子落水的地点属于兰州红古区平安镇,自己家两个孩子被水卷走,是政府对水电站监管不严的结果,大坝泄洪前无任何通告,属于安全漏洞,政府也有责任。

当地宣传部门表示,目前,当地区镇两级还在继续配合家属全力开展搜救工作,同时,对家属上访的问题积极作好解释和疏导。(来源:中国青年报)

netease本文来源:中青在线-中国青年报 责任编辑:杜磊_NN2415

陕西省增加1例本土确诊病例:为西安海外工作人员防护酒店餐厅工作专班组员******

  12月8日0时-12月9日7时,增加汇报当地确诊病例1例。

  12月8日0-24时,增加汇报海外键入确诊病例1例、没有症状的感染者1例,没有症状的感染者消除密切接触1例。

  截止到12月9日7时,总计汇报当地确诊病例264例,在院2例、康复259例、身亡3例。

  截止到12月8日24时,总计汇报海外键入确诊病例451例,康复440例、在院11例。总计汇报海外键入没有症状的感染者425例,变为确诊病例52例、消除密切接触361例、尚在密切接触的没有症状的感染者12例。

  当地确诊病例:向某,男,21岁,为西安市灞桥区海外工作人员隔离酒店餐厅工作专班组员。向某承担为隔离工作人员外卖送餐、搜集废弃物和消杀工作,并分別于12月5日、12月8日担负海外键入核酸检测呈阳性旅客屋子的消毒每日任务。12月8日在隔离酒店餐厅全部领导小组工作员按我国规定开展隔天一次核酸检测中,向某的单取样本核酸检测結果为呈阳性,12月9日1时经西安市市疾控中心复查結果为呈阳性。12月9日5时,经地市级专家团专家会诊,确诊为新冠肺炎确诊病例(轻形)。基本具体分析,向某感柒缘故为领导小组工作员间断性职业暴露而致,现阶段向某已被装运至医保定点医院隔离医治,西安已对该隔离酒店餐厅领导小组工作员就地隔离监管,其它工作已经进行中。

  海外键入确诊病例:林某,男,33岁,新疆省籍,为12月4日由塔吉克斯坦伊斯兰堡至西安市PK854飞机航班旅客。该飞机航班抵达西安市咸阳国际机场后,飞机航班所有工作人员贯彻落实中国海关检验检疫、核酸检测、点到点装运等闭环对策,无山西省内自主活动轨迹。隔离期内核酸检测結果呈阳性,经地市级专家团专家会诊,确诊为新冠肺炎确诊病例,现阶段在医保定点医院隔离医治。

  海外键入没有症状的感染者:女,26岁,外国籍,为12月7日由首尔至西安市KE9807飞机航班旅客。该飞机航班抵达西安市咸阳国际机场后,飞机航班所有工作人员贯彻落实中国海关检验检疫、核酸检测、点到点装运等闭环对策,无山西省内自主活动轨迹。核酸检测結果呈阳性,经地市级专家团专家会诊,确诊为新冠肺炎没有症状的感染者,现阶段在医保定点医院隔离密切接触。



来源于:山西省卫健委。

编缉:曹静。

沪漂小哥花15万买房车当家还因此找到女友:住2年回本

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